From Business: Located at I-55 and Highway K, the Pear Tree Inn Cape Girardeau Medical Center is located next door to Saint Francis Medical Center and just moments away from Southeast…

From Business: Located directly off I-55, Drury Suites Cape Girardeau is the perfect stop for business or leisure travelers. At the heart of Cape Girardeau, the hotel is just minutes away…

From Business: The Town House Inn Cape Girardeau is located just 2 miles away from the Southeast Missouri State University, show me center sports venue, Isle Casino and Downtown. Our Rooms…

"One of the nicest mid-range hotels I've have stayed at. Great staff, beautiful lobby and rooms. Will be back next time."

From Business: From our daily free hot breakfast to our nightly cookie hour, Hampton Inn Cape Girardeau I-55 East makes you feel at home. Located on the southeast corner of I-55 and William…

From Business: Best Western Plus Jackson/Cape Girardeau hotel in Jackson, Missouri! Our hotel is located just off I-55 at Exit 99. This hotel offers 80 rooms including 9 suites.Best Western…

"It was my first time staying at a Best Western and I enjoyed it. I was suprised to see how much space we had in our room. But, it was a good amount of space for the cost of the…"

From Business: Motel 6 Sikeston is an excellent choice for travelers visiting Sikeston, offering a budget friendly environment alongside many helpful amenities designed to enhance your stay.…

From Business: See why so many travelers make Comfort Inn & Suites Sikeston their hotel of choice when visiting Sikeston. Providing an ideal mix of value, comfort and convenience, it offers a…

From Business: This wyndham Hotels affiliate is a all Suite property with large bedrooms and living rooms, 2 LED television in each room, located near restaurants, Sikeston Jaycee Bootheel…

From Business: The Fairfield Inn and Suites is Cape Girardeau's newest property by Marriott that features a saltwater pool, fitness center, and a free hot breakfast to fuel up your stay.…

From Business: Whether traveling for business or fun, Courtyard by Marriott® makes all your travels successful by providing what you need: spacious, thoughtful guest rooms and services that…

From Business: See why so many travelers make Eagle Inn their motel of choice when visiting Charleston. Providing an ideal mix of value, comfort and convenience, it offers a budget friendly…