General Info

As one of the most innovative restaurants in San Diego, we are committed to sustainability and true farm-to-table restaurant experience, we work with the best ingredients from locally grown produce, hormone-free grass fed meat, wild seafood, and antibiotic free Mary’s chicken. With an eclectic and unique menu offering, we accommodate all dietary restrictions ranging from gluten-free, vegetarian, and vegan. We like to say that it is always happy hour at Cafe 21. We’re serving up brunch, dinner and a complete line of craft cocktails every day of the week. With the best Happy Hour in downtown San Diego running daily from 3 PM to 6 PM to our nightly live local music, an unforgettable experience awaits you at Cafe 21!As one of the most innovative restaurants in San Diego, we are committed to sustainability and true farm-to-table restaurant experience, we work with the best ingredients from locally grown produce, hormone-free grass fed meat, wild seafood, and antibiotic free Mary’s chicken. With an eclectic and unique menu offering, we accommodate all dietary restrictions ranging from gluten-free, vegetarian, and vegan. We like to say that it is always happy hour at Cafe 21. We’re serving up brunch, dinner and a complete line of craft cocktails every day of the week. With the best Happy Hour in downtown San Diego running daily from 3 PM to 6 PM to our nightly live local music, an unforgettable experience awaits you at Cafe 21!