Welcome to Our Yankton, South Dakota Hotel Allow this beautiful town to lure you into its pristine surroundings, which support a wealth of outdoor activities. Just 30 miles west of Interstate 29, our property boasts a convenient location to nearby area attractions. As one of the best hotels in Yankton, SD, our facility is designed just for you with all the modern amenities and comforts that you need. Corporate guests looking for hotels in Yankton, SD need look no further than this Holiday Inn Express hotel which offers a well-equipped business center, free high-speed, wireless Internet access and 700 square feet of flexible meeting space. We are just a short drive from businesses like Sapa, Kolberg Pioneer, Shurco, Lewis and Clark Specialty Hospital and Avera Sacred Heart Hospital. Families can enjoy a stress free trip when they stay with us in Yankton, SD.