Our HistoryIn the year 2002, six brothers from Guanajuato, Mexico were working in the restaurant industry in Southern California. One day, these six Medrano brothers, Francisco, Jose, Jesus, George, Ramiro and Zorro decided they would open their own restaurant. The idea for Medranos Mexican Restaurant was born. That same year, they opened Medranos Mexican Restaurant in Lancaster. After much success, they opened the Palmdale location in 2005.Today Medranos is well known in the Antelope Valley. It is family owned and operated and the place to go when you want delicious, authentic Mexican food in "the AV.